Stem-cell vote could put California at center of biotech universe

By Ceci Connolly
The Washington Post

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Crafted by a group of parents, scientists, Hollywood stars and venture capitalists, the proposal to spend $3 billion on embryonic stem-cell research is a virtual end-run around the Bush administration that would put this state far ahead of most other nations in a promising — and controversial — new field of medicine.

While President Bush and his Democratic rival, Sen. John Kerry, squabble over whether to invest $25 million or $100 million of federal money in the field, Californians are considering a radically different course. In defiance of Bush's limited national policy, Californians are being asked to pour 10 times as much money into a state program, letting voters for the first time decide whether to invest tax dollars in a specific type of research.

If the bond measure is approved, supporters say, it would revolutionize the fledgling science — with California and its legions of academic laboratories and biotech firms at the epicenter. The payoff, proponents say, could be treatments for chronic conditions such as diabetes, Parkinson's disease and spinal-cord injury.

Opponents counter that the price would be high, in both moral and financial terms. To pursue those treatments, scientists must destroy 5-day-old embryos, a process that Roman Catholic leaders here call a "direct attack on innocent human life." Payments on the bonds would cost the state nearly $6 billion over 30 years, a sum many say California cannot afford.

The creators of Proposition 71 have assembled a powerful cast of advocates, from Republican Gov. Arnold Schwarzenegger to Nobel Prize winners, from the head of the Bush administration's stem-cell task force to the late actor Christopher Reeve, who appears in a commercial taped shortly before his death. Other supporters include the California Chamber of Commerce, actor Michael J. Fox, who has Parkinson's, and George Shultz, secretary of state under President Reagan.

On the other side is a collection of unlikely allies — feminists who fear the demand for embryos will create "egg farms," fiscal conservatives and evangelical Christians. They are short on famous names and even shorter on cash.

Although national polls show that more than 70 percent of Americans endorse embryonic stem-cell research, recent state polling puts support for the bond proposal at about 50 percent. By historical standards that would not bode well for passage, because late-deciding voters tend to oppose initiatives. However, a deluge of pro-initiative ads could tip the balance.

"The fact that this is on the ballot at all is a stunning testimonial to the power of citizen advocacy," said Mary Woolley, president of the nonpartisan Research America, which promotes public investment in science.

Yet what Woolley and proponents hail as democracy in its purest form, others see as an abuse of the electoral process — a small, well-funded constituency using emotion to sell expensive, unproven science.

"This is taking billions of dollars from desperately needed health care to support this science project," said H. Rex Greene of Mills-Peninsula Health Services in San Mateo. "If this ever leads to cures, it will be decades away — if ever."
 
To patients and families, embryonic stem cells offer a spark of hope. They speak in urgent tones of not having time to waste on political haggling. Scientists are enthusiastic about cells taken from embryos because they have the unique ability to morph into almost any type of tissue or cell, potentially replacing diseased or damaged tissue with healthy, self-renewing replacements, in some cases grown from a patient's own cells.

To date, researchers mostly used frozen embryos that would otherwise have been discarded by fertility clinics. Proposition 71 would allow California scientists to use state money to work with such embryos or to create new ones in a laboratory by cloning.

In August 2001, Bush decided to limit federal support to only the cell colonies, or "lines," that had already been created — touted to be more than 60 at the time, but in reality a couple dozen viable lines. His compromise reflected an attempt to balance "good science with good ethics," he said recently.

Lynn Fielder, a 42-year-old mother who takes half a dozen pills every three hours to manage her Parkinson's, sees the ethical dilemma differently. "It would be absolutely irresponsible to not be pursuing something like this," she said. "What can be more moral than saving the lives of people who exist and easing the burden on their families?"

A few other states have passed "safe harbor" legislation allowing embryonic stem-cell research, and New Jersey is poised to spend $5 million a year on it, but none approaches the ambition of the California measure. California real estate developer Bob Klein, who has a son with diabetes and a mother with Alzheimer's, designed the bond proposal so that the state would not make payments for the first five years, an approach that helped sway Schwarzenegger.

With Klein's $2.5 million as seed money, the group Cures for California has raised more than $24 million, with large checks from wealthy donors such as Microsoft's Bill Gates and Sen. Jon Corzine, D-N.J., advocacy groups such as the Juvenile Diabetes Research Foundation and numerous venture capitalists.

Opponents, who have raised less than $200,000, describe those donations as a thinly veiled financial grab by special interests. "A group of venture capitalists spent about $5 million to access $6 billion in taxpayer money," said Tom Bordonaro, a former state lawmaker. "That's a pretty good return on investment."

This weekend, on television sets across the state, Reeve delivers the final appeal for the initiative. The spot is introduced with a message from his family explaining they "wished to honor his memory by airing this, his last recorded message." From his wheelchair, the paralyzed actor — who died Oct. 10 — urges: "Please support Prop. 71 — and stand up for those who can't."