Originally published May 3, 2007 at 12:00 AM | Page modified May 3, 2007 at 2:01 AM
Report touts new drug to fight osteoporosis
A yearly 15-minute infusion of a new drug substantially reduces bone fractures in post-menopausal women, offering a new treatment option...
Los Angeles Times
A yearly 15-minute infusion of a new drug substantially reduces bone fractures in post-menopausal women, offering a new treatment option for women who have trouble taking existing bone-strengthening drugs, researchers reported today.
Although drugs such as Fosamax and Actonel are effective at preventing bone loss and reducing the major health risks associated with fractures, as many as half of women stop taking them within six months because of the complicated regimen required and the risk of side effects.
The new drug, zoledronic acid, "requires an encounter with the medical establishment only once a year, so there is no problem with compliance and adherence," said Dr. Robert Recker of the Creighton University School of Medicine in Nebraska.
The drug also avoids the esophageal problems that are common with the oral drugs, said Recker, who is vice president of the National Osteoporosis Foundation and was not involved in the study.
The three-year study of 7,736 post-menopausal women found a 70 percent reduction in the risk of spinal fractures and a 40 percent reduction in the risk of hip fractures.
"But even more remarkable were the strong, significant and consistent effects across all fracture types," said epidemiologist Dennis Black of the University of California, San Francisco School of Medicine, who led the study.
The results were "impressive," wrote Dr. Juliet Compston of the University of Cambridge School of Clinical Medicine in Britain in an editorial accompanying the report in The New England Journal of Medicine.
The drug is sold by drug maker Novartis in the U.S. under the brand name Zometa to treat Paget's disease — a genetic disorder in which bone becomes soft and breaks down readily — and the prevention of bone loss in cancer chemotherapy. The company is applying to the Food and Drug Administration to sell it under the name Reclast for treating osteoporosis.
About 10 million people in the U.S. suffer from osteoporosis, and an additional 34 million have low bone density, which puts them at risk for the disorder, according to the osteoporosis foundation.
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